Mitochondrial dysfunction is directly related to excess fatigue. Fatigue is considered a multidimensional sensation that is perceived to be a loss of overall energy and an inability to perform even simple tasks without exertion.[01,02] Although mild fatigue can be caused by a number of conditions, including depression and other psychological conditions, moderate to severe fatigue involves cellular energy systems.[01,02] At the cellular level, moderate to severe fatigue is related to loss of mitochondrial function and diminished production of ATP.[02-04] Intractable fatigue lasting more than 6 months that is not reversed by sleep (chronic fatigue) is the most common complaint of patients seeking general medical care.[01,05] Chronic fatigue is also an important secondary condition in many clinical diagnoses, often preceding patients’ primary diagnoses.[05-06] As a result of aging and chronic diseases, oxidative damage to mitochondrial membranes impairs mitochondrial function.[07-09] As an example, individuals with chronic fatigue syndrome present with evidence of oxidative damage to DNA and lipids,[09,10] such as oxidized blood markers[11] and oxidized membrane lipids,[12] that is indicative of excess oxidative stress. These individuals also have sustained, elevated levels of peroxynitrite due to excess nitric oxide, which can also result in lipid peroxidation and loss of mitochondrial function as well as changes in cytokine levels that exert a positive feedback on nitric oxide production.[13]
Mito9 supports Mitochondria and increases ATP energy transfer. Ninety-eight percent of the oxygen we breathe is used by tiny powerhouses within our cells known as the Mitochondria, which converts sugar, fats, and inorganic phosphates by combining with oxygen into adenosine triphosphate (ATP), widely recognized by modern medicine as the universal form of energy the human body requires to live and function.
This energy producing activity of the mitochondria involves a series of intricate, complex and vital biochemical processes that depend on a vast number of anywhere from 500 to 10,000 sets of oxidative enzymes. These enzymes depend on dozens of critical nutrient factors and co-factors that are ideally derived from phytonutrient rich fruits and vegetable sources from an optimal diet.
Unfortunately, the modern diet is lacking many of these key nutrient factors and co-factors and thus widespread exhaustion, energy depletion and a generally tired public are now the norm.
Mito9 is to fill the missing link or gap in the depleted modern diet and provide some of these nutrients that are so critical to energy production in the human body. In addition, during the metabolism process a very small amount of left over oxygen loses electrons, creating a free radical burden on the body which can and often does trigger energy depletion, accelerated aging of cells and rapid cell mortality.
This happens when the free radicals literally burn holes in the cell membranes. For instance, as calcium penetrates cells through the free radical caused holes in cell membranes, it results in cell death and thus weakens the tissues and organs, exhausting cellular energy and resulting not only weakness of tissues and organs but cell death. Dead cells don’t produce energy.
When this kind of damage continues, the body literally becomes “rusty”, unable to move due to low energy production and compromised immune function can then lead to health challenges such as cancer, heart disease (hardening of the arteries), diabetes, premature aging and other bodily disorders. Many modern medical doctors claim that mitochondrial dysfunction is at the root of every disease there is, including fatigue.
Mitochondria are the primary intracellular site of oxygen consumption and the major source of reactive oxygen species (ROS), most of them originating from the mitochondrial respiratory chain.
Among the arsenal of antioxidants and detoxifying enzymes existing in mitochondria, mitochondrial glutathione (mGSH) emerges as the main line of defense for the maintenance of the appropriate mitochondrial redox environment to avoid or repair oxidative modifications leading to mitochondrial dysfunction and cell death. mGSH importance is based not only on its abundance, but also on its versatility to counteract hydrogen peroxide, lipid hydroperoxides, or xenobiotics, mainly as a cofactor of enzymes such as glutathione peroxidase or glutathione-S-transferase (GST).
Many death-inducing stimuli interact with mitochondria, causing oxidative stress; in addition, numerous pathologies are characterized by a consistent decrease in mGSH levels, which may sensitize to additional insults. From the evaluation of mGSH influence on different pathologic settings such as hypoxia, ischemia reperfusion injury, aging, liver diseases, and neurologic disorders, it is becoming evident that it has an important role in the pathophysiology and biomedical strategies aimed to boost mGSH levels.
Mito9 is made for hard working, playing and exercising people that desire more energy to fill their busy and active lifestyles, but who also at the same time are looking for convenient ways to increase their health and vitality long-term. Finding the energy for work and family responsibilities is hard enough. Throw in a second job, go back to school, or simply have a sleepless night, and you’re bound to hit the wall.
